01:146:328 Lecture Notes - Lecture 21: Malaria, Hepatocyte, Plasmodium

• School: Rutgers University
• Department: Cell Biology and Neuroscience
• Course: 01:146:328
• Professor: A.Keating

Document Summary

Sporozoites: short-prepatent (no symptom period, invade hepatocytes, undergo schizogany and develop into merozoites, leave hepatocytes, invade rbcs, long-prepatent, invade hepatocytes, undergo schizogany and develop into merozoites, remain in hepatocytes hypnozoites, stuck in exo-erythrocytic cycle. Relapse patient has vivax malaria, recovers & then in normal health. Hypnozoites in liver escape and invade rbcs: merozoites. Only penetrate rbcs with duffy antigen on surface. Duffy antigen is a receptor for chemokines. If fya or fyb present merozoite can penetrate. If fy = no receptor merozoite cannot penetrate: duffy negative individual resistant to vivax malaria. Stippling small surface invaginations = schuffner"s dots: plasmodium malariae. Ring stage: when mature, elongates band forms. Trophozoite: ziemannn"s dots small, less numerous stippling. Recrudescence: sick and recover many years later sick again. Sudden increase in persistent, low level, undetected parasite population in blood: stuck in erythrocytic cycle, no blood donation, fever every 72 hours, plasmodium ovale.