01:146:356 Lecture Notes - Lecture 2: Antigen, Granulocyte, Thrombin

• School: Rutgers University
• Department: Cell Biology and Neuroscience
• Course: 01:146:356
• Professor: Gary Merrill

Document Summary

Thrombopoiesis: creation of thrombocytes (ligations of cytoplasm of megakaryocytes) Two types of white blood cell types. Named for cytoplasmic granules that appear _____ when stained. Including: eosinophils (red) basophils (blue) neutrophils (intermediate red or blue) T-cells: responsible for cell-mediated immunity, most abundant. B-cells: can turn into plasma cells which can secrete antibodies against specific antigens; responsible for humoral (protective) immunity. Mature in bone marrow and lymphoid tissue. Monocytes: migrate from bone marrow to peripheral tissue, not abundant in blood. Develops into a macrophage (geek: large eater) that 1) engulfs pathogens or cellular debris, and 2) presents antigen to lymphocytes. Alpha granules: store clotting factors like fibrinogen. Dense core granules: store energy factors like phosphates (adp and atp), essential for hemostasis. Hemostasis: process in which bleeding is made to cease/stop. Platelets are responsible for plugging small breaches in the vascular e(cid:374)dotheliu(cid:373), this process is three steps lo(cid:374)g .