01:377:370 Lecture Notes - Lecture 21: Packed Red Blood Cells, Iron-Deficiency Anemia, Volume Fraction
11 Apr 2019
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For each 1 mmhg pressure, 0. 003ml o2 dissolves into plasma. This results in ~3 ml of o2/liter blood. With 5l total blood volume = 15 ml dissolved o2. This would really only sustain us for about 4 seconds. Dissolved o2 establishes the po2 of the blood. Each of four iron (fe) atoms associated with hemoglobin combines with one o2 molecule. Reaction requires no enzymes- dictated by po2 in physical solution. Each gram of hb comines with 1. 34 ml o2. Under normal conditions, with normal hb levels: each dl of blood contains about. Slightly lower in women due to less hb/dl blood= helps explain slightly lower aerobic capacity of women. Bottom line: 65-70 times more o2 is carried this way than normally dissolves in plasma. Anemics don"t have as much iron and then can"t carry oxygen. Volume percent (vol %) refers to millimeters of oxygen extracted from a 100ml sample of whole blood or packed red blood cells.
