14:440:301 Lecture 3: Pharmaceutical Chemistry Dr Hu Lecture Three

• School: Rutgers University
• Department: General Engineering
• Course: 14:440:301
• Professor: All

Document Summary

We have neurons connecting to each other, between the neurons there is a synapse. There is a signal transmission that has to be done with neurotransmitter chemicals. You have enzymatic metabolism to convert neurotransmitter into something else that cannot react with receptor or it can be reuptaken. Know about the receptors involved in each transmitters (what types of receptors are involved) The ones we look at last time, there is acetyl choline (which is class of itself) it is a neurotransmitter for the cholinergic nervous system. Acetyl chline has an ester bond that is unstable, that will be hydrolyzed in the presence of esterases. You also have a basic quandary ammoniom cation that is positively charged (very water soluble). So in the synapse there is acetyl choline esterase that can quickly break down the ester bond and break it into acetic acid and choline. Choline can be taken back and stored and reused for synthesis of acetyl choline.