01:447:245 Lecture Notes - Lecture 3: Cytokine, Macrophage, Transforming Growth Factor Beta
Document Summary
Major risk factors with more common oral squamous cell carcinoma. Cigarette smoke : provides 2- to 4- fold greater risk. Oral squamous cell carcinoma is associated with the amount of alcohol/cigarette exposal of the individual. Best with lip lesions - 5 year recurrence free rate 90% Poorest with tumors in the floor of mouth and base of tongue yielding to only. Keratin is a molecule secreted by differentiated squamous epithelial cells (keratinocytes) The more de-differentiated or transformed the squamous becomes, the less likely it is to secrete a differentiated molecule such as keratin (closer to normal cell than other cells) *younger, not as aggressive i. ii. Keratin pearls suggest more differentiated cancer in those areas, and less differentiated where keratin pearls are present. Tumor- acute inflammation persists in the "wounded area" and transitions to. During chronic inflammation, pro-inflammatory cytokines are produced by chronic inflammation neutrophils and macrophages that persist in the area.
