01:830:331 Lecture Notes - Lecture 21: Ligand-Gated Ion Channel, Choline, Nociceptor
24 Jul 2016
School
Department
Course
Professor
Document Summary
~all axons of sensory systems in the brain use glutamate (except for nociceptors) ~the other nt (other than gaba and glutamate) are more modulatory. They can stimulate certain regions of the brain, and the cells within those regions use. ~main nt secreted be efferent axons in pns, that is, the axons that are sending info away from brain. ~also in ganglia of ans and target organs of parasympathetic branch in ans. ~after ach is released in the synaptic cleft and you need to get rid of it, the enzyme acetylcholinesterase (ache) breaks it down into choline and acetate choline is recycled by cell to make more ach. ~muscle cells have ionotropic receptors, because they need rapid response. ~metabotropic receptors have slower and more prolonged response. ~in the cns, there are both types of receptors, but more metabotropic. ~botulinum toxin prevents release of ach and causes paralysis. ~curare is a direct antagonist, drug that block ionotropic ach receptors, causes paralysis.
