ENS 307 Lecture Notes - Lecture 10: Medial Globus Pallidus, Substantia Nigra, Subthalamic Nucleus
23 Mar 2020
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Document Summary
A progressive degenerative disorder of the cns. The motor symptoms result from the death of cells in the substantia nigra, a region of the midbrain. Functions to provide a feedback mechanism to the cerebral cortex for the initiation and control of motor responses. Out of the bg is mediated through the thalamus. Dampen or reduce excitatory input to the cortex. Putamen receives fibers from motor regions of the cerebral cortex. Caudate nucleus receives inputs from association regions (temporal and parietal lobes) and frontal lobe. Circuits of the basal ganglia: caudate nucleus and putamen to globus pallidus (external and internal, caudate nucleus and putamen to substantia nigra, globus pallidus and subthalamic nucleus. The circuits transmitting signals back to the motor cortex back be direct or indirect. Caudate nucleus and putamen to internal globus pallidus. Caudate nucleus and putamen globus pallidus (internal) and substantia nigra. Neostriatum globus pallidus (external) subthalamic nucleus medial globus pallidus thalamus cerebral cortex.
