ENS 332 Lecture Notes - Lecture 16: Colorectal Cancer, Prostate Cancer, G1 Phase
5 Nov 2016
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Document Summary
Cancer" is a collection of ~100 different diseases: all cancers are slightly different. Us prevalence: ~4% of population is living with some form of cancer. Us incidence: ~460 new cases per year, per 100,000 people, ~40% lifetime chance of developing cancer of some sort. Mortality: 2nd leading cause of death in us, ~25% of all deaths (non-accidental) Men: most common occurrence: prostate, lung, and colorectal, mortality: lung, prostate, and colorectal. Women: most common occurrence: breast, lung, and colorectal, mortality: lung, breast, and colorectal. Population growth and aging are the primary drivers. ** aging is the strongest risk factor for cancers. Gap 0 (g0) post-mitotic phase: might be senescent or quiescent cells. Cells stop dividing and eventually die: cells might exit the cell cycle, if they are post-mitotic. Or cells fully differentiated that do not renew like neurons: some cells, like the epithelial cells, will not enter g0, and just keep the cycle going for life.
