ENS 332 Lecture Notes - Lecture 22: Antigen, Genome Editing, Immunoglobulin G
9 Dec 2016
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Adaptive immunity b lymphocytes (immunoglobulins igg, igm) ~10,000 membrane bound antibodies, each b cell having slightly different antibodies. Immune 2: each b cell is different from the next, but they all have the exact same dna. There is random shuffling in the dna. Constant region the same, but dna replication during differentiation leads to variable portions slightly different: due to random chance because the dna replicases don"t behave perfectly consistently. Natural variation in the variable region of the antibody. Variable regions are due to shuffling of the dna (random assembly diversity) Total combinations work out to >1 trillion ((cid:2778)(cid:2777)(cid:2778)(cid:2779)) different combinations of receptors, Strategy: recognize pathogen, might be antigen presented by apcs (dendritic cell, macrophage, etc. , bind antigen, phagocytosis, present antigen via mhc ii, differentiate to memory b cells and plasma cells. Memory b cells lasts for decades; amplify b cells that have receptors for pathogens you encounter during your life.
