BIOL 103 Lecture Notes - Lecture 10: Santa Barbara City College, Atp Hydrolysis, Signal Peptide

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Genomes of mitochondria and chloroplasts are much smaller than genomes of bacteria. Because some genes were probably lost since their functions aren"t needed in intracellular environment or are duplicated by functions of nucleus-encoded proteins. Other genes from these genomes have been transferred to the eukaryotic nucleus. Net result is that majority of all mitochondria and chloroplast proteins are encoded by nuclear genes. Only a few highly hydrophobic protein subunits are encoded by mitochondrial genes and synthesized on ribosomes in the mitochondria. Means that almost all proteins in mitochondria and chloroplasts are synthesized on free ribosomes in the cytosol and are then targeted to mitochondria or chloroplasts. There is a specific targeting signal that is located at the n-terminal end of proteins destined for mitochondria and chloroplasts. Import of mitochondrial matrix proteins and is very similar to import of stromal proteins.

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