PHYS 799 Lecture Notes - Lecture 4: Vegf Receptor, Angiopoietin, Vascular Endothelial Growth Factor
12 Oct 2018
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Document Summary
Angiogenesis is the sprouting of new capillaries from pre-existing vascular. Introduction structures, which largely involves the proliferation of endothelial cells that line blood vessels. Angiogenesis is involved in processes such as growth and development, wound healing, menstruation, and exercise. Vasculogenesis is de novo formation of blood vessels which requires differentiation of endothelial cells from precursors. There is evidence that vasculogenesis occurs in adults, but only in a limited capacity. excessive angiogenesis occurs in cancer, atherosclerotic plaque formation, diabetic retinopathy (blindness), and rheumatoid arthritis. Processes that require growth or involve inflammation promote angiogenesis. Some diseases such as stroke and atherosclerosis involve insufficient angiogenesis. Factors such as inflammatory cytokines, g-protein coupled receptors, integrins, and tgf can mediate angiogenesis. These factors act via growth factors and receptor tyrosine kinases (rtks). Rtks such as vegf receptors, angiopoietin, and eph receptors, are expressed in endothelial cells and promote angiogenesis when activated.
