PHYS 799 Lecture Notes - Lecture 42: Bare Lymphocyte Syndrome, Human Leukocyte Antigen, Ankylosing Spondylitis

• School: USC, SC, Carolina, South Carolina
• Department: PHYS - Physics
• Course: PHYS 799
• Professor: Smith

Document Summary

Professional apcs macrophages, dendritic cells, b cells. T cell receptors (tcrs) recognize peptides bound to mhc. Cd8 (cytotoxic) t cells kill infected/abnormal cells (which present endogenous ags on mhc i) Cd4 (helper) t cells assist professional apcs (which present exogenous ags on mhc ii) Cross-presentation (endogenous ag, if dendritic cell not infected) dendritic cell phagocytoses infected cell, transports ag into cytoplasm for proteasome degradation and presentation to cd8 cells on mhc i. Mhc i alpha (3 domains, polymorphic) and beta (1 domain, invariant) chains; peptide binding site formed by alpha-1 and alpha-2 domains. Mhc ii alpha (2 domains, invariant) and beta (2 domains, polymorphic) chains; peptide binding site formed by alpha-1 and beta-1 domains (-note: human mhc is aka hla human lymphocyte antigen) Degenerate specificity of mhc molecules binding via key aa anchor residues , regardless of what other aa"s are thus, mhc will bind family of related peptides.