THEA 101 Lecture 6: Exam 2 Biochemistry Study Guide
Document Summary
It has a pseudouridine loop and d loop and these are conserved and invariant and have hydrogen bonding in between the loops. In 3o structure, the cloverleaf folds to form an l shape. This is also stabilized by hydrogen bonds and base stacking occurs. Describe forces involved. bonding likely will not be able to occur between base pairs. It will also destabilize nucleic acid structure, wherever it is position. It may also affect absorbance, it may not absorb at 260 nm. stacking would become destabilized. This would cause water"s entropy to decrease, thus rna would not be stable. This would allow for base pairing to also be prevented, thus, hydrogen bonding would be interrupted, again, destabilizing the helix. Absorbance would be altered, it would not absorb at 260 nm. If a methyl is present, it will likely disrupt hydrogen bonding and base pairing. If a hydrophobic molecule is present (ex. phenyl), the hydrophobic forces stabilizing base.
