BIO 310 Lecture Notes - Lecture 9: Tyrosine Kinase, E2F, Myc
Document Summary
Tyrosine kinase binds to tkr, activating the pathway. Immediate early response - activates myc transcribes genes to activate g1-cdk. Cdk phosphorylates rb, causing it to dissociate from. E2f induces expression of genes that will cause cell to. Reduced nutrients will slow down cell cycle. G phase is for growing and cells need the nutrients to grow to an adequate size. Without cell cycle control, the cells will keep dividing even if it is not large enough to. How dna damage arrests the cell cycle in g1. When dna is damaged, certain kinase activations phosphorylate p53 destabilizes interaction with mdm2. Accumulation of p53 acts as transcription factor. Binds to regulatory region of p21 gene (cki) cki transcribes p21 mrna. P21 binds to cyciln-cdk complex, stopping it from progressing further into the cell cycle until damage is fixed. Cell cycle arrest can be induced by excessive amounts of myc. This leads to the activation of arf, which binds to and inactivates.
