BIO 361 Lecture Notes - Lecture 23: Enol, Triose, Tautomer
10 Jul 2016
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Document Summary
In cells that lack the capacity to make 1,3-bpg because the start of the catalytic pathway is compromised by, for example, deficiency of the enzyme hexokinase, subsequent intermediates molecules cannot be made. Therefore, hemoglobin affinity for oxygen will be high in this state (deficient 2,3-dpg). A cell that fails to break down 2,3-dpg or its products tends to result in accumulation in 2,3-dpg. Therefore, hemoglobin affinity for oxygen will be low in this state (abundant 2,3-dpg). Pyruvate kinase is an enzyme that breaks down products of 2,3-dpg, and individuals who lack this enzyme tend to have an abnormally high levels of 2,3-dpg. The conversion of 2pg to phosphoenolpyruvate (pep) is carried out by hydration or dehydration. The product of this conversion to pep is another example of a high energy phosphate. Pep is as reactive as mixed anhydrides, such as 1,3-bpg. The removal of water from 2pg generates this high energy phosphate, pep.
