NURS 4390 Lecture Notes - Lecture 9: Coronary Artery Disease, Coronary Circulation, Cardiac Muscle Cell
3 May 2020
School
Department
Course
Professor
Document Summary
Cardiac anatomy: a review: four chambers, four valves, myocardium: heart muscle, cardiomyocytes: cardiac cells. Oxygenated blood: lv aortic valve aorta coronary arteries cardiomyocytes. Plaque buildup, endothelium starts to get damaged occludes coronary arteries. #2 still have good blood supply, but beginning of coronary disease. Coronary arteries constrict sob, chest pain. Non-modifiable: age, gender, ethnicity, family history, genetics. Modifiable: elevated serum lipids, cholesterol, hdl, ldls, extra cholesterol attaching to the lining, htn, chronic pressure, tobacco use, vasoconstriction, physical inactivity, weight, diabetes, diet. Of blood flow to myocytes, if ischemia does not reverse which leads to infarction. Relieved by rest or medications, do not exert themselves. Ekg returns to baseline when activity stops. Chest pain at rest: plaque ruptures. Cardiomyocytes release enzymes when cells lose oxygen, toxins build up in cardiomyocytes causes the membranes to become leaky releases enzymes. Ck-mb: onset: 3-6 hrs, peak: 10-24 hrs, duration: 10-14 days, onset: 6 hrs, peak: 18 hrs, duration: 2-3 days.
