NEU 211 Lecture Notes - Lecture 7: Cochlea, University Of Manchester, Tas1R2
18 May 2016
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1:1 ratio; therefore, having a small amount of antibody won"t work as well. Mix in other antibodies that can bind to the first antibody that allows for amplification of the signal. Yum yum yum yum in my tum tum tum. Approximately 50-100 taste cells found in each taste bud: circumvallate (thousands in humans, foliate (dozens-hundreds, fungiform (5-10) 4 cell types: basal, light, dark, intermediate. Trcs are non-neuronal but they are electrically excitable and fire action potentials. Labelled-line model: each cell has one receptor that brings only that taste to the specific ganglion cell. Across-fibre model: each cell has various receptors for a variety of the different tastes. Primary tastants || sour, sweet, umami, bitter, salty. Evolutionary background: we need to know where to get yummy things, avoid bad things. Salt | enac changes the activity of amiloride-sensitive na+ channels alters the excitability of certain salt-sensitive taste cells. Dta expression in adult mice: genetic ablation of pkd2k1 containing cells.
