NSD 481 Lecture Notes - Lecture 4: Vitamin B12 Deficiency, Megaloblastic Anemia, Macrocytic Anemia
10 Oct 2016
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A deficiency in the size or number of red blood cells (rbc) or the amount of hemoglobin they contain. Causes limited gas exchange (o2 and co2) between blood and tissues. Hemoglobin-large protein (4 polypeptide chans and 4 iron groups) that carries o2 in blood. Serum: the liquid part of whole blood, no additives. Plasma: the liquid part of whole blood if a clotting factor or other additive was added to the sample. Mean corpuscular volume (mcv) a measure of rbc size. Two overall types of anemia: nutritional anemia"s. Iron, vitamin b12, folate, others (deficiencies: non nutritional anemia"s. Chemotherapy, hemolytic anemia, hemorrhage, renal disease, cirrhosis, leukemia, multiple myeloma. Mcv >94 (mean corpuscular volume) ex: vitamin b12 or folate deficiency (mchc will be >30) Mcv <80; mchc <31 ex: fe-deficiency anemia; any disorder of fe metabolism; thalassemia. When fe is short supply, body (intestines) increases absorptive capacity. Transferrin=a protein that transports fe (from gi tract, storage sites, or.
