BIOL 3327 Lecture Notes - Lecture 33: Myasthenia Gravis, Edrophonium, Acetylcholine Receptor
15 Jul 2020
School
Department
Course
Professor
Document Summary
Stimulation, with occasional subsequent depression, of cholinergic receptor sites in the cns (both muscarinic and nicotinic) pesticides: homicide and suicide. Vapor exposure leads to: ocular and respiratory effects miosis, ocular pain, conjunctival congestion, diminished vision, bronchoconstriction and increased bronchial secretion. Ingestion leads to: nausea and vomiting, abdominal cramps, and diarrhea. Severe intoxication: extreme salivation, involuntary defecation and urination, sweating, lacrimation, bradycardia, and hypotension. Neuromuscular junctions of skeletal muscle: fatigability, generalized weakness, involuntary twitchings, scattered fasciculations, and eventually severe weakness and paralysis. The most serious consequence is paralysis of the respiratory muscles. See edrophonium somatic synapses reversal of toxic anticholinergic effects. Older clinical uses are the covalent bond of ophthalmic: miosis, the carbamylated enzyme is glaucoma more resistant to the second (hydration) process, 30 min to. Reversal of effects of nondepolarizing neuromuscular blocking agents after surgery. Stimulation, followed by depression or paralysis, of all autonomic ganglia and skeletal muscle (nicotinic actions)
