BIOL 3327 Lecture Notes - Lecture 38: Orthostatic Hypotension, Thiazide, Collecting Duct System
15 Jul 2020
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Document Summary
By preventing the na from coming into the cell, you change the concentration gradient between the blood and the cell. Even without pth, we have the concentration gradient being very high in the blood, and coming into the cell and it drives even more ca2+ into the blood. Thiazide diuretics actually increase the amount of calcium the patient will reabsorb. Good for patients with osteoporosis because thiazide diuretics are the diuretics of choice because it helps to pull more ca2+ out of the kidney. Changes in k+ that happens later on in the collecting ducts, but not as dramatic. Thiazide and thiazide-like diuretics: two secondary mechanisms of action. Both thiazides and loops will trigger increases in prostaglandins as a secondary mechanism, helping decrease na+ reabsorption, then water in the collecting duct to reduce blood volume and blood pressure. If you block cyclooxygenase, you block the synthesis of prostaglandins, thus affecting the third mechanism as well.
