BIOL 3327 Lecture Notes - Lecture 37: Cytochrome C Oxidase Subunit Ii, Drug Interaction, Hypomagnesemia
15 Jul 2020
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Document Summary
Loop diuretics acts by blocking the lumenal side transporter. Na+, cl-, ca2+, and mg2+ reabsorption, as well as less k+ because we"re not bringing it in and driving that atpase as much as we used to. We"re losing the back pressure of the k+ and we lose the pressure to take in ca2+ and mg2+. Patients who are on loop diuretics need to be monitoring their levels of ca2+ and. Major pharmacological effects of reducing na+ (good for hypertension), reducing water reabsorption in later segments (good for reabsorption), but we lose ca2+ and mg2+, as well as k+ later. Good news: produces the greatest loss of na+ and water. (but that water loss happens later on in the pathway). Renal prostaglandins are synthesized locally, in the kidney, when needed (autacoids) Bind to pge2 receptors; they have effects just to normally help regulate na+. These compounds trigger an increase in cox2, which synthesizes prostaglandins from arachidonic acid.
