BIOL 3327 Lecture Notes - Lecture 51: Ejection Fraction, Coronary Artery Disease, Carotid Sinus
15 Jul 2020
School
Department
Course
Professor
Document Summary
A progressive disease; a gradual decrease over time of cardiac performance. Punctuated episodes of very serious decompensated episodes: Systolic failure: when you have reduced contractility the heart muscle cell. Ejection fraction less than 45% (person is getting less blood ejected into their system) Causes: coronary artery disease, ischemia, hypertension, dilated cardiomyopathies (drug use, viral infections, etc) Enlarged heart, the muscle gets bigger to compensate for the lack of good function, so you get a puffed out left ventricle. Diastolic failure: more and more common; when the cardiac muscle gets stiff and we have a loss of adequate relaxation resulting in reduced filling and cardiac output. Ejection fraction can stay the same even though the push/stroke of volume is decreased. The muscle is getting thick and it"s becoming less efficient. Even though you"re ejecting blood, the ventricle is getting smaller and less functional. Reduce the symptoms and slow the progression. Maintenance phase ; the drugs we use are different.
