BIOL 4376 Lecture Notes - Lecture 26: Reassortment, Antiviral Drug, Antigenic Drift
3 Jul 2020
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Rna polymerase makes mistakes! (error prone to small changes; change can lead to outbreak) Abrupt, major changes in ha or na. Caused by genetic reassortment between human, swine, or avian influenza viruses. Moa: inhibit uncoating after it enters the cells blocks release of viral rna into cell. Moa: inhibit influenza virus neuraminidase enzyme, preventing the release of viral particles from infected cells. Moa: inhibits endonuclease activity of a selective polymerase acidic (pa) protein, which is required for viral gene transcription, resulting in inhibition of influenza virus replication. Dosing: 40mg as a single dose within 48 hours of onset of symptoms. Alleviates symptoms faster than a placebo in adolescents and adults. Superior to both placebo and tamiflu in antiviral activity. Associated with the respiratory tract, isolated chiefly from the nose and throat. Due to protein capsid, rhinovirus is most infectiou as tempuratures below normal body temperature. High titers can be found in nasal secretions as early as 2-4 days after exposure.
