BIOL 4376 Lecture Notes - Lecture 34: Aspergillus Fumigatus, Lung Transplantation, Itch
3 Jul 2020
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Caused by the mucorales phylum of molds. Acidic conditions (especially with diabetes in crisis) Germination of sporangiospores in the nasa passages. Hyphae invade blood vessels, causing thrombosis, infarction, necrosis. Can progress to sinuses, eyes, cranial bones and brain. Part of the normal flora of the skin, respiratory tract, oral + genital mucous membranes, Candidiasis is the most prevalent systemic mycosis. C. albicans: most common - germ tube production. Widespread use of fluconazole has lead to azole-resistant strains in these two species. In culture/tissue, they grow as ova, budding yeast cells. Pseudohyphae: continue to grow but fail to detach producing chains of elongated cells that are pinches at the separations between cells. On agar within 24 hours at room temperature, the species produce soft, cream colored colonies with a trademark yeasty odor. Cutaneous or mucosal candidiasis is established by an increase in the local population of candida. Damage to the skin or epithelium that permits local invasion.
