NSG 3315 Lecture 13: Chapter 13 - Disorders of RBCs
Document Summary
Disorders of red blood cells: alterations in oxygen. Rbc"s contain hemoglobin for o2 to bind to. Iron causes reddish appearance when oxygenated and bluish when deoxygenated. Iron is stored in tissue like the liver as ferritin, a protein-iron complex. Erythropoiesis - production of rbc in the bone marrow. Maturation of rbcs: erythroblast - baby red blood cells reticulocyte erythrocyte. If there is a decrease in o2 anywhere in the body > kidneys release erythropoietin (hormone) into the blood > stimulates rbc production or erythropoiesis in the bone marrow. Destruction occurs in the liver, spleen, bone marrow, and lymph nodes. Amino acids and iron are reused; the rest is converted to bilirubin increased rbc destruction = bilirubin = jaundice. Reticulocyte count = rate of red blood cell production. Hemoglobin = hemoglobin content in the blood (caries o2 to cells and carries co2 away from cells ) Hematocrit = volume of cells in 100ml of blood.
