BIOL 221 Lecture Notes - Lecture 6: Kupffer Cell, Monocyte, Neutrophil
1 Mar 2020
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Phagocytes: macrophages: derived from monocytes, lysosomes & mitochondria abundant, think-spot: what are the functions of these organelles and why is having more of them good, free (wandering) macrophages (e. g. , dust cells, fixed macrophages (e. g. , kupffer cells of liver) Macrophages are large phagocytes derived from monocytes. They contain large number of lysosomes and mitochondria. (what are the functions of these organelles and why is having more of them good?) Free, or wandering, macrophages such as dust cells of the lung alveoli move freely through tissues. Fixed macrophages such as kupffer cells of the liver stay in one place. Associated with chronic infections: aid adaptive immunity by acting as apcs. Macrophages are slower to act and longer-lived than neutrophils. They aid adaptive immunity by acting as antigen-presenting cells (apcs). Neutrophils, also called microphages, are the first phagocytes to respond during a bacterial infection; therefore, they are associated with acute, localized bacterial infections.
