BIO 115 Lecture Notes - Lecture 28: T Helper Cell, Cetirizine, Basophil
Document Summary
List the two second generation h1 blockers that also block the h4 receptor on mast cells, basophils and eosinophils. No drugs selectively target it, but others block it too. H4 receptor inhibition - inhibits release of mast cell mediators. Has some sedative effects as it is a metabolite from hydroxyzine. Inhibits mast cell degranulation via h4 receptor blocking. List the pharmacological approaches used to treat airway disorders and link these approaches to dr. kalhan"s lecture material on asthma and copd. Epi for anaphylaxis increases cardiac contractility (b1 agonists) Asthmatic attack in the ed: use synergy (albuterol + ipratropium) Albuterol is a saba, all other terols are labas. Side effects are usually due to improper inhaler use. Stops mast cell migration, cox/loc pathway,cytokines, th2 release, eosinophil attraction and activation. Not only blocks migration, but also blocks cytokine release and synthesis. Leukotriene results in: bronchoconstriction, vascular permeability, mucus secretion, inflammatory cell infiltration.
