BIO 121 Lecture Notes - Lecture 2: Glycoprotein, Alpha Helix, Amphiphile
23 Nov 2020
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Transmembrane proteins: extent the entire membrane + have bits that extend out: held by hydrophobic aa side chains within the hydrophobic core of the membrane. Lipid -anchored proteins: proteins covalently attached to fatty acid/diacylglycerides embedded in the membrane. Peripheral membrane proteins: commonly attached to the membrane through associations with integral membrane proteins: involve several types of non-covalent interaction or ionic/hydrogen bonds. Must be more than one alpha helix. Must be hydrophilic on the ends, polar on the inside, this would differ depending on what the channel is used for. Not stable enough on its own exposed backbone does not interact easily with hydrophobic core of the bilayer: solution, the beta-sheet folds on itself, there is no backbone. Structural anchors that attach the membrane to organelles, extracellular matrix, or other cells (ie. linkers connect multiple proteins in the membrane to provide shape) Transport mediate transport of different molecules in either direction.
