BSC 114 Lecture Notes - Lecture 20: Punnett Square, Mendelian Inheritance, Genetic Variation

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Genetic variation produced in sexual life cycles contributes to evolution. Mutations (changes in the nucleotide sequence of an organism"s dna) are the original source of genetic diversity. Reshuffling of different versions of genes during sexual reproduction produces genetic variation. The behavior of chromosomes during meiosis and fertilization is responsible for most of the genetic variation that arises in each generation. Homologous pairs of chromosomes orient randomly at metaphase i of meiosis. In independent assortment, each pair of chromosomes sorts maternal and paternal homologs into daughter cells independently of the other pairs. The number of combinations possible when chromosomes assort independently into gametes is 2n, where n is the haploid number. For humans (n = 23), there are about 8. 4 million (223) possible combinations of chromosomes. Crossing over produces recombinant chromosomes, which combine genes inherited from each parent. Crossing over begins very early in prophase i, as homologous chromosomes pair up gene by gene.

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