BSC 116 Lecture Notes - Lecture 24: Antimicrobial Peptides, B-Cell Receptor, Innate Immune System
27 Aug 2016
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Document Summary
Acquired immunity and immunological memory: complex interactions among various cell types, including b and t cells. Mhc proteins: genetic shuffling as a source of variation, clonal selection enhances immune response, humoral and cell-mediated immune response. Immune systems are necessary for multicellular animals (and plants) Internal environment of organism good for cells & cellular processes: lots of nutrients, etc. Pathogens: foreign invaders that try to co-opt organismal resources; cause disease: prokaryotes, eukaryotes: protists & fungi (+ animals, viruses. Immune system necessary to avoid/ limit infection: keep foreign invaders out, recognize self vs. non-self once invaders inside, detection of non-self accomplished by molecular recognition. Among vertebrates, there are two levels of immunity: innate & acquired immunity. Innate immunity: active all the time (i. e. , not dependent on previous infection), non- specific: found in all animals (even sponges) and plants, inhibit/ detect broad range of pathogens, first defense, only line of defense in invertebrates.
