BSC 431 Lecture Notes - Lecture 15: Shigella Sonnei, Shigatoxigenic And Verotoxigenic Escherichia Coli, Shigella Flexneri

• School: University of Alabama
• Department: Biological Sciences
• Course: BSC 431
• Professor: Julie Olson

Document Summary

Penetrates and multiplies w/in epithelial cells of the colon. Bacteria are engulfed, lyse the endosome and replicate in the host cytoplasm (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Bacteria can move to adjacent cells and can cause ulceration. Bundle forming fimbriae mediate agglutination of cells in a stacked brick formation. Exist in a biofilm on the intestinal surface (cid:1) Heat stable (east) and plasmid-encoded (pet) toxins induce fluid secretion (cid:1) (cid:1) (cid:1) (cid:1) Prone to abscess formation and necrosis: bloody sputum. Also cause urinary tract infections, wound and soft tissue infections. Raises ph, precipitates ca and mg forming kidney stones, damaging bladder lining. Creates diagnostic problems in the lab: swarming, lack of lactose fermentation, hydrogen sulfide formation. Responsible for nosocomial infections: wound infections, utis. Looks pink growing on tile grout (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Members are closely related to e. coli and shigella. Dna homology indicates that the genus consists of 2 species: