BSC 431 Lecture Notes - Lecture 37: Zanamivir, Cardiovirus, Vpg

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Replication in macrophages, the liver, or endothelial linings of vessels can amplify the infection and initiate the development of a secondary viremia (cid:1) Often preceeds delivery of virus to the target tissue and the appearance of symptoms (cid:1) Viruses may disrupt the endothelial lining of vessels to traverse the blood-brain barrier (cid:1) (cid:1) (cid:1) There are 3 potential outcomes of a viral infection of a cell: failed infection, cell death (lytic infection, infection w/o cell death (persistent infection) Largely determined by the ability and speed w/ which the immune system controls the infection. Also based on the nature of the exposure, the immune status (eg age, general health) of the individual, viral dose, and the genetics of the host and virus (cid:1) (cid:1) (cid:1) Examination of tissue samples can provide a rapid initial diagnosis for viruses that produce a characteristic cytopathic effect (cpe) Inclusion bodies (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Can be used if sufficient particles are present.

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