HHE 378 Lecture Notes - Lecture 15: Lamotrigine, Electroconvulsive Therapy, Phenothiazine
12 Nov 2017
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Antipsychotics: treatment considerations: treatment with antipsychotics found to be more effective than a placebo, patients relapse when therapy is discontinued, two groups of antipsychotics, conventional (introduced before mid 1990s, atypical (introduced in the past 10 years) Improve negative symptoms (slower to think, move, talk; indifferent to social contact; change in sleep patterns) of schizophrenia- an effect not seen from conventional antipsychotics. Antidepressants: major types: monoamine oxidase inhibitors (maoi, examples: phenelzine, tranylcypromine, tricyclic antidepressants, examples: amitriptyline, doxepin, nortriptyline, selective serotonin reuptake inhibitors (ssris, examples: fluoxetine, sertraline, venlafaxine. Antidepressants: mechanism of action: appear to work by increasing the availability of norepinephrine or serotonin, a lag period before improvement in mood is seen, we do(cid:374)"t yet ha(cid:448)e the co(cid:373)plete picture of ho(cid:449) a(cid:374)tidepressa(cid:374)ts (cid:449)ork. Electroconvulsive therapy: most effective treatment for relieving severe depression, works very rapidly, more quickly than antidepressant drugs, best treatment choice in cases with a risk of suicide, can be used in conjunction with drugs.
