BIO 201 Lecture Notes - Lecture 20: Oxaloacetic Acid, Atp Synthase, Decarboxylation

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Aerobic metabolism: glycolysis is universal among all species on earth, but aerobic and anaerobic a. i. Always in the cytoplasm for every species: evolved when o2 levels increased in the atmosphere, complete oxidation to co2 d. Harvest energy in nadh and fadh2 to make atp e. ii. 1. Cannot use the energy immediately, but can harvest it f. The first two pathways are the oxidation of pyruvate to co2 f. iii. Capture energy from nadh and fadh2 to create h+ gradient f. iii. 2. Uses the energy from the battery to drive synthesis of atp from. Adp: you can get about 30 more atp than glycolysis alone. Eukaryotes have to move out of the cytoplasm: pyruvate needs to be in the mitochondria, all of aerobic metabolism happens in the mitochondria. Anatomy of pyruvate oxidation and the citric acid cycle: pyruvate is oxidized to co2 inside the matrix of the mitochondria, energy harnessed to make gtp (atp), nadh, and fadh2 c.

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