BIO 201 Lecture Notes - Lecture 18: Competitive Inhibition, Pepsin, Peptide
11 Apr 2017
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Regulation of enzymes ensures that: enough product is made, only enough product is made, reactants are available for given processes, toxic intermediates don"t accumulate. Binding of a compound other than substrate, but similar, to the active site a. iii. 1. Cell produces only as much product is necessary a. vi. The substrate, which may be used in other pathways, is conserved a. vii. Many chemical weapons and insecticides: allosteric ( other shape ) regulation b. i. A molecule binds to a location on enzyme other than the active site b. v. This leads to a conformational change of active site b. vi. Activator molecule binds to allosteric site resulting in a conformational change b. viii. 2. Enzyme is active only in presence of activator b. ix. Allosteric inhibitor binds somewhere other than active site, causing a conformational change in active site that prevents substrate binding b. ix. 2. Enzyme is active only in absence of inhibitor b. x. The cell produces only as much product as needed b. x. 2.
