BIO 319 Lecture Notes - Lecture 24: Lambda Phage, Shiga Toxin, Lysogenic Cycle
Document Summary
Materials for previous lectures that are needed for comprehension. Sigma factor ( factor): is a protein needed for initiation of transcription in bacteria. It is a bacterial transcription initiation factor that enables specific binding of rna polymerase to gene promoter. Camp act as an activator in the lac operon analogy to how cll needed for pre promoter activation. This is important to understand since many bacterial disease are actually the result of lysogenic. Phage within the bacteria, the gene for the toxins resided in the phage of the dna (ex: e. coli and shiga toxin that is produced by a phage that is close to lambda) Prophage: phage dna integrated into the host genome. Rna virus: utilizes rna polymerase which doesn"t have proofreading mechanism hence very high mutation rates. Phages can follow two life cycles either lytic life cycle or the lysogenic life cycle. Always looking for new victim since these destroy the population.