ES 340 Lecture Notes - Lecture 5: Impaired Glucose Tolerance, Gestational Diabetes, Diabetes Mellitus Type 1

• School: University at Buffalo
• Department: Exercise Science
• Course: ES 340
• Professor: Gosselin

Document Summary

Diabetes= metabolic disease characterized by absolute or relative insulin deficiency results in hyperglycemia (cid:862)a(cid:271)solute(cid:863)= (cid:374)o i(cid:374)suli(cid:374) p(cid:396)ese(cid:374)t at all (cid:862)(cid:396)elative(cid:863)= (cid:373)o(cid:396)e i(cid:374)suli(cid:374) (cid:396)e(cid:395)ui(cid:396)ed to (cid:272)lea(cid:396) the sa(cid:373)e a(cid:373)ou(cid:374)t of glu(cid:272)ose. Absolute insulin deficiency: pancreatic beta cell decrease. Hyperglycemia/ketoacidosis: bod(cid:455) (cid:272)a(cid:374)"t utilize glu(cid:272)ose a(cid:374)d (cid:271)egi(cid:374)s to use ffas a(cid:374)d a(cid:373)i(cid:374)o a(cid:272)ids. Omnipod: easy to use, waterproof, no tubes, built-in glucose meter, pump malfunction, battery life, scar tissue. Screening (24-28weeks: manifests in third trimester, placenta hormones interfere with insulin signaling cascade. ~20-50% will develop type ii diabetes within 5-10 years. Hyperglycemia: decreased glucose uptake, fasting blood glucose (mg/dl), <100 = normal, 100-125 = impaired fasting glucose (ifd, >125 = diabetes, ogtt (2hrs, 140-200 = impaired glucose tolerance (igt, >200 = diabetes. Indicated average glucose levels over a 3 month period: non-diabetics: 20-41mmol/mol (4-5. 9%, diabetics: 48mmol/mol (6. 5%, diabetics at higher risk of hypoglycemia: 59mmol/mol (7. 5%)