MIC 301 Lecture Notes - Lecture 24: Shingles, Molluscum Contagiosum, Neonatal Herpes Simplex
30 Mar 2016
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Document Summary
Most animal poxviruses are species speciic unable to infect humans because cannot atach to human cells. Infecion inhalaion of virus and close contact (necessary) All poxviruses produce lesions that progress through stages: macule, papule, vesicle, pustule, crust, scar. Features: large virions, large genome, ds dna viruses (larger than herpesviruses, have capsids and envelopes, replicate in cytoplasm of infected cell, must have own mrna and dna syntheic machinery can be a bioweapon. Variola major cause disease with 20% mortality rate. Variola infects internal organs, causing fever, malaise, and delirium. Moves via blood to skin, where it produces pox. 1st human disease to be eradicated due to: inexpensive, stable, and efecive vaccine, no animal reservoirs, virus needs to be in close contact. Edward jenner used cowpox to immunize individuals against small pox. Increase in monkeypox cases in humans over past decade caused by molluscipoxvirus skin disease characterized by smooth, waxy papules face, trunk, and external genitalia.
