MIC 401 Lecture Notes - Lecture 1: Neonatal Tetanus, Risus Sardonicus, Botulinum Toxin

• School: University at Buffalo
• Department: Microbiology And Immunology
• Course: MIC 401
• Professor: Amy Jacobs

Document Summary

Clostridium botulinum: histotoxic clostridia - (gas gangrene) Opportunistic pathogens that require a special environment to initiate growth: traumatized tissue, vascular damage, necrotic tissue, decreased oxygen, perfringens produces a large number of exotoxins and extracellular enzymes such as: collagenase proteinase deoxyribonuclease. Clostridial wound infections: anaerobic myonecrosis (gas gangrene, anaerobic cellulitis, anaerobic myonecrosis. Ever widening expansion of necrotic lesion to adjacent healthy muscle tissues. Symptoms local edema gas production - h2 and co2 change of skin color to black generalized fever pain in infected tissue. 1. surgical procedures in close proximity to intestinal microflora - bowel surgery, abortions. 4. removal of dead tissue (debridement) application of antiserum (polyvalent antitoxin) broad spectrum antibiotic - penicillin or tetracycline hyperbaric o2 chamber: anaerobic cellulitis. Symptoms - similar to anaerobic myonecrosis but of a lesser severity. 1: synthesis of enterotoxin in small intestine, enterotoxin produced which breaks down intestinal mucosa leakage of plasma membrane disruption of osmotic equilibrium.