PMY 302 Lecture 36: Antibiotics- Cell Wall Agents
20 Dec 2018
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Document Summary
Disrupts the cell wall which is made by crosslinking the peptides from nam and nag via. Breakage of alanine produces energy for transpeptidase. Thiazolidine ring + beta - lactam = apa. Looks like peptide but even more stable than the peptides in. Covalent bonding to the enzyme: very strong. Results in cell lysis due to osmotic pressure. Hyperkalemia, painful im, allergy, hapten (small molecule that causes. Peng: gram +, no acid stability, lactamase sensitive: streptococci. Oxacillin (methicillin not used anymore): gram +, acid stable, beta. Ampicillin (amoxicillin): both gram + and gram -, acid stable, lactamase an allergic reaction when combined with protein) lactamase resistant: staphylococci sensitive: h. influenza. Augmentin: combined with clavulanic acid (itself isn"t an antibiotic but deactivates the lactamases) Piperacillin: same as ampicillin but also pseudomonas. Se: bleeding, thrombophlebitis, dose reduction in renal impairment. 2nd generation: increased g- coverage, decrease g+ coverage: 3rd generation: more g- coverage, decrease g+ coverage, csf.
