BSCI 222 Lecture 21: Lect. 21 & Ch. 18
9 Dec 2016
School
Department
Course
Professor
Document Summary
Somatic vs. germline mutations somatic mutation (p. 494) Mutations that arise in somatic tissues, which do not produce gametes. Somatic mutations occur in nonreproductive cells and are passed to new cells through mitosis, creating a clone of cells having the mutant gene. germ-line mutation (p. 495) Mutations that arise in cells that ultimately produce gametes. Germ-line occur in cells that give rise to gametes. Meiosis and sexual reproduction allow germ-line mutations to be passed to approximately half the members of the next generation. 1 rem = tissue damage from 1 rad. A quick first screen using a procaryotic system. Looks for reversions of various mutant alleles changes a mutant phenotype back into the wild type. Testing for cancer on laboratory animals is expensive and time consuming. Testing cancer on animals is not very indicative for whether or not it will cause cancer in humans because of animals are very different from humans. Bruce ames developed the ames test in 1974.
