BSCI 105 Lecture Notes - Lecture 11: Basal Metabolic Rate, Hypothalamus, Osmotic Concentration
11 Jul 2016
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Resource limited: more protein can be made from carbs, nucleic acids, and lipids. Cells regulate the enzymes of catabolism and anabolism. If so, it will have high levels of adp, nad+, and coa. If not, it will have high levels of atp, nadh, and acetyl-coa. Phosphofructokinase: committed step of glycolysis, phosphorylates fructose-p, inhibited by atp. Atp is a substrate for this reaction. Pyruvate dehydrogenase: is found in both active and inactive forms, allosteric regulation. Something binds to it, alters its shape, and it no longer functions: found in active form if: Adp or amp (adenosine monophosphate) is high. Nadh is highly unstable so the cell doesn"t want to make more: found in inactive form, ^ vice versa than it needs. Isocitrate dehydrogenase: converts isocitrate to -ketoglutarate, inhibited by nadh and atp, activated by nad+ and adp, when shut down, citrate and isocitrate accumulate. In the event of too much acetyl coa.
