BIL 330 Lecture Notes - Lecture 2: Neanderthal Genome Project, Habitat Fragmentation, Allele Frequency

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28 Apr 2016
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Why is phylogenetics: studies the evolutionary history of a group by using a phylogenetic tree, includes the pattern, and timing of events as species/populations diversified. Hardy-weinberg equilibrium (means there is no evolution: p2 (frequency of allele 1) + 2pg (hybrid) + q2 (frequency of allele 2, when this is violated (aka evolution occurs) Drive alleles to fixation or maintain genetic variation. Necessary for evolution as ultimate source of variation. Large effects on allele frequency esp. in small populations. Over time will lead to fixation of a single allele. Doesn"t directly affect changes in allele frequency. Can"t predict genotype frequency based on allele frequency. Uses microsatellite loci (if you are more similar in these markers you are more related to one another) Evidence we came from africa (african population split from everyone else early on, then europe split, than south america split, then asia split: human population genetics. Genetic variation (from chromosome 12) decreases as you leave africa (done by tishkoff)

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