MIC 321 Lecture Notes - Lecture 14: Mhc Class I, Interferon Gamma, Follicular B Helper T Cells

• School: University of Miami
• Department: Microbiology and Immunology
• Course: MIC 321
• Professor: Williams Roger

Document Summary

Understand that the environment of a professional apc at the time of the antigen sampling in the periphery controls which kind of t-cell effector function will be generated in the lymph node. Dc programmed early on and picks up part of antigen and displays it in lymph node to activate na ve t cells (cd8 become cytotoxic) and (cd4 become th1, th2, th17, thelper and induced. Understand that intracellular pathogens (presented by professional apc in the context of mhc class i) activate t-cells to kill host cells with intracellular pathogens (by default) Cd8 are intracellular and for viruses and such. Detection of intracellular pathogens promotes cd8 cell activation: nk cells and macrophages produce il12 and interferon gamma, dc primed to become strong antigen presenting cell to activate cytotoxic t cells. Slide 9 shows na ve cytotoxic t cell except most of the cell is the nucleus. 12: how cd8 cytotoxic t cells kill their targets ^, ligands for death receptors.