MIC 321 Lecture Notes - Lecture 24: Cancer Immunology, Tumor Suppressor Gene, Adaptive Immune System
28 Apr 2016
School
Department
Course
Professor
Document Summary
Benign tumors don"t spread and are encapsulated and localized. Malignant tumors increase in size and invade tissues: treatment = surgery, radiotherapy or chemotherapy. Pathway removes cells that have mutations to stop us getting cancer. 10: many viruses help the progress to cancer. Cancer cell characteristics: they develop a blood supply = angiogenesis, grow quickly and avoid apoptosis death. Tumor-specific antigen = mutant peptide from cellular protein presented. Mic protein = stress protein = target for nk cells. Tumors can cleave mic to escape immune system to prevent nk activation: lots of tumors also shut down/express very low levels of mhc class 1. 25: another target is pd1 (programmed death protein, tumor cells express pdl1 and pdl2. 32: using radioactive ab to bind to malignant b cells and kill them. All of these process are good at shrinking tumor bulk and killing a lot of these cells and prolong survival, but rarely do they cure it.
