PSIO 199 Lecture Notes - Lecture 5: Arthrofibrosis, Chemical Synapse, Supraspinatus Muscle
2 Mar 2017
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Document Summary
Deep tissue scaring (creating scar tissue): macrophages activate fibroblast through tgf-b. (tissue growth factor- beta, other tissue is replaced by collagen and glycosaminoglycans. Sudden involuntary muscle contraction: can be caused by: Sudden tightening of muscle fibers: caused by overuse. Produced by clostridium botulinum: causes inactivation of muscle contractions, works on presynaptic terminal, prevents snare proteins from creating acetylcholine vesicles. Produced by clostridium tetani: an agonist of acetylcholine, competes with acetylcholine, works on postsynaptic terminal. Autoimmune disorder: an antagonist of acetylcholine, competes with acetylcholine, works on postsynaptic terminal. Blocks or destroys nicotinic receptors: associated with: Can be caused by a viral infection: herpes simplex virus type 1 (hsv-1, herpes zoster (shingles, causes inflammation of cranial nerve vii. Blocks signal or destroys nerve due to increase pressure. Affects muscle: facial (expression, eye, tongue (affects movement, speech, and taste) Genetic disorder: duchenne, becker"s, fascioscapulohumerla, myotonic.
