PSIO 303A Lecture Notes - Lecture 43: Nmda Receptor, Glutamate Transporter, Chemical Synapse
5 Dec 2016
School
Department
Course
Document Summary
Block 3 - lecture 13 - outside influences on cells. A chemical synapse has a lot of moving parts (these parts are different in a pre and postsynaptic cell) It depends on the coordinated function of parts that our cells can achieve the following outcome: Action potentials reach axon terminals ==> voltage-gated ca2+ channels open ==> ca2. + binds to sensor proteins in cytoplasm ==> ca2+ dependent protein complex stimulates fusion and exocytosis of neurotransmitter (nt) Synapse function can be changed at many different points: Changing the amount or activity of vglut transporters ==> changes size and number of vesicles vglut amount is linked to protein synthesis vglut activity is linked to h+, atpase signaling pathways and metabolism. The chemical synapse is susceptible to changes, regardless of these changes being good or bad. For example, botox interferes with ach release at the neuromuscular junction (nmj) Botox on nt release (interferes with presynaptic terminal and stops the vesicle-filled.
