PSIO 303A Lecture Notes - Lecture 12: Adipocyte, Adiponectin Receptor 1, Adiponectin Receptor
25 Sep 2016
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Lecture 12 - adipokine action: consequences of obesity in the metabolic syndrome. Lecture objectives of adipokine action - consequences of obesity in the metabolic syndrome: Discuss the concept that central obesity is a key component of the metabolic syndrome. Factors produced by this fat depot (adipokines) are linked to the dysfunctions and increased cardio risk factors displayed by individuals with this syndrome. List regulatory mechanisms that underlie the secretion, vascular transport, and cellular action of adiponectin. Describe the defects in adiponectin secretion and cellular action associated with the obesity- related insulin resistance of the metabolic syndrome. It"s an appetite regulator and energy expenditure modulator. Increased leptin --> changes in proliferation and rate of apoptosis --> changes in beta-cell size. Long term damage is found when leptin is produced at long term. Stimulates crp (c-reactive protein) from the liver --> insulin resistance --> contributes to pro-inflammatory state. Bmi associated disease risk (from cefalu and cannon, 2007):
