PSIO 303A Lecture Notes - Lecture 22: Ouabain, Atp Hydrolysis, Serca
24 Oct 2016
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Block 2 - lecture 7 - primary active transport. Net transport of a substrate against its electrochemical gradient. The energy required to move the substrate against its electrochemical gradient has to come from a source other than the substrate"s own ec gradient. There are two sources of energy that can be used to support movement of a substrate against its. Ec gradient - the two sources of energy lead to the classification of the two types of active transporters: E. g. energy derived from direct hydrolysis of atp by the transporter. Uses the free energy from atp hydrolysis to move a substrate against its ec gradient. Primary active transport can be split into two categories: In mammals, this class of processes transports potentially toxic compounds out of the cell. However, this can lead to the transporters pumping drugs out of the cell which leads to a decrease in drug effectiveness = mdr. Like all carrier-mediated transport they are saturable and selective.
