BIOL 2213 Lecture Notes - Lecture 3: Muscarine, Curare, Atropine
8 Sep 2016
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Convergence versus divergence: convergence a bunch of synapses connect with one neuron, divergence - a bunch of neurons connect with one synapse. Function anatomy of synapses: electrical pre and post-synaptic cells are connected by gap junctions. Found in cardiac, smooth muscle and cns o: chemical. Pre-synaptic neurons release neurotransmitter from their axon terminals. Neurotransmitter is a messenger that travels across the space and binds to receptors on post-synaptic neurons o. Mechanisms of neurotransmitter release: action potential down axon terminal arrives at terminal triggers voltage gated channel calcium ions released trigger change in snare proteins leads to fusion & release of neurotransmitter o. Postsynaptic response can be excitatory or inhibitory: excitatory. Open na+ and k+ channels moving lots of na in and small amount of k out: net movement is + into the cell. Brings postsynaptic membrane closer to threshold depolarizing. Open cl or k+ channels, cl in or k out is negative. Brings postsynaptic membrane further from threshold hyperpolarizing.
